Di-tert-butyl dicarbonate

Fa'amatalaga Puupuu:

Igoa o oloa:Di-tert-butyl dicarbonate

upu uiga tutusa:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, malo/suavai

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Vaega o oloa:Vailaau Fa'atekonolosi; Amata Mea Mata & Intermediates; Amino Acid Derivatives; Organics; N-Protecting Reagents; Biochemistry; Peptide Synthesis; Puipuiga & Derivatization Reagents (mo le Synthesis); Puipuiga Reagents (Peptide Synthesis); Fa'asologa o vaila'au Boc-Amino; Su'esu'ega Eseese; DIBOC; 1H-Inden-1-ol;bc0001;24424-99-5

Mol File:24424-99-5.mol

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Fa'amatalaga Oloa

Faailoga o oloa

Di-tert-butyl dicarbonate Meatotino Vailaau

Liu liusuavai	23 °C (malamalama)
Fa'apuna	56-57 °C/0.5 mmHg (malamalama)
mafiafia	0.95 g/mL ile 25 °C (malamalama)
mamafa ausa	3.85Pa ile 25℃
fa'asino fa'asino	n20/D 1.409(me.)
Fp	99 °F
vevela vevela.	2-8°C
fomu	Ma'a'a Va'a Fa'ameamea
lanu	Lanu pa'epa'e
Gravity Fa'apitoa	0.950
Suavai Solubility	Fa'afefiloi ma le decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, ava malosi, acetone, acetonitrile ma le dimethylformamide.Le fa'afefiloi ma le vai.
Ma'ale'ale	Susū ma'ale'ale
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 ile 25℃
CAS Fa'amaumauga Fa'amaumauga	24424-99-5(Fa'amatalaga Fa'amaumauga a le CAS)
Faiga Fa'atusitala a le EPA	Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

Fa'amatalaga Saogalemu

Laiti o lamatiaga	T+,T,F,Xi,F+
Fa'amatalaga Tulaga lamatia	11-19-26-36/37/38-43-10-40
Fa'amatalaga Saogalemu	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Siamani	3
RTECS	HT0230000
F	4.4-10-21
Fa'avevela le vevela	460 °C
Mata'utia Fa'amatalaga	Mumu/Itaitai/Toe Oona
TSCA	Ioe
Vasega lamatia	6.1
PackingGroup	I
HS Code	29209010
Oona	LD50 tuugutu ile Lapiti: > 5000 mg/kg LD50 dermal Lapiti > 2000 mg/kg

Di-tert-butyl dicarbonate Fa'aoga ma le Fa'asologa

Meatotino tau vailaau	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) e leai se lanu e pa'epa'e ma samasama tioata, fa'ama'a fa'ama'a po'o le vai manino.E liusuavai i le vevela o le potu (mp=23°C).E le pala i lenei mea po'o le maualuga teisi foi o le vevela.Mo se fa'ata'ita'iga, e masani lava ona fa'amamāina e ala i le fa'amama i lalo o le fa'aitiitia o le mamafa i le vevela e o'o atu i le 65°C.I le maualuga o le vevela o le a pala i le isobutene, t-butyl alcohol ma le carbon dioxide.
Fa'aoga	O le Di-tert-butyl dicarbonate (Boc2O) o se fa'aoga lautele e fa'aaogaina mo le fa'aofiina o vaega puipuia i le peptide synthesis.E iai sona sao taua i le sauniuniga o le 6-acetyl-1,2,3,4-tetrahydropyridine e ala i le tali atu i le 2-piperidone.E avea o se vaega puipuia o loʻo faʻaaogaina i le faʻaogaina o le peptide faʻamalosi.
Sauniuniga	O le sauniuniga o le Di-tert-butyl dicarbonate o loʻo faʻapea: I se monoester sodium salt solution na faʻaopoopoina 2g o N, N-dimethylformamide, 1g o pyridine, 1g o triethylamine, Faʻamafanafana i le -5 ~ 0 ° C, 60g diphosgene sa faifai malie. faaopoopo dropwise i totonu ole 1.5h dropwise faaopoopo faaopoopo ua atoatoa, mafanafana i le vevela potu (25°C), incubated mo 2h, le tali na faatagaina e tu pe a uma filtration, fufuluina vaifofo organic.Fa'agogo i le magnesium sulfate anhydrous, o le solvent na fa'amama ese i le mamafa o le ea e tu'uina atu ai mea leaga 65 ~ 70g.A maeʻa le malulu ma le faʻamalama, 57-60g o di-tert-butyl dicarbonate na maua i se fua o le 60-63%.
Uiga	ChEBI: Di-tert-butyl dicarbonate ose acyclic carboxylic anhydride.E feso'ota'i fa'atino ma se vaila'au dicarbonic.
Tali	O le tali atu a sui o aniline ma Boc2O i le i ai o se aofaiga stoichiometric o le 4-dimethylaminopyridine (DMAP) i totonu o se solvent inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) i le vevela o le potu e oʻo atu ai i aryl isocyanates i totonu ole 10 yie. min. Di-tert-butyl dicarbonate ma le 4-(dimethylamino)pyridine toe asia.O latou tali i amine ma ava malosi
Fa'amatalaga Lautele	Di-tert-butyl dicarbonate (Boc₂O) o se reagent e masani ona faʻaaogaina mo le faʻaofiina o le vaega puipuia o le Boc i le amine functionalities.E fa'aaogaina fo'i e fai ma sui e fa'amama ai le vai i nisi o gaioiga fa'alenatura, ae maise i vaila'au carboxylic, nisi vaega hydroxyl, po'o ni nitroalkanes muamua.
Tulaga lamatia	O se fa'aitaitagofie e ono mafua ai se manu'a tuga o mata;E ono fa'aoso ai le pa'u;O'ona maualuga pe a manava
Mumu ma le Pa	Mumu
Auala Fa'amamāina	Liusuavai le ester e ala i le faʻamafanafanaina i le ~ 35o, ma faʻafefe i totonu o se masini.Afai o le IR ma le NMR (1810m 1765 cm-1, i le CCl4 1.50 singlet) e fautua mai e matua'i le mama, ona fufulu lea i se voluma tutusa o le H2O o lo'o i ai le citric acid e fai ai le aqueous layer ia sina acidic, aoina le mea fa'aola ma fa'ago i luga ole MgSO4 anhydrous. ma fa'a'a'ele'elea i totonu o se masini.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] MUA.