N-Methyl-2-pyrrolidone

Fa'amatalaga Puupuu:

Igoa o oloa:N-Methyl-2-pyrrolidone

upu uiga tutusa:M-PYROL(R);1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (e KF));1-Methyl-2-pyrrolidinone(99.5%, HyDry, with molecular sieves, Water≤50 ppm (saunia e KF));N-Methyl-2-pyrrolidone Tufuga;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT ( ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Vaega o oloa:NMP;mea fa'ameamea;UV/Vis);GC Headspace Solvents;GC Solvents;Solvents mo talosaga GC;ACS ma Reagent Vasega Solvents;ACS Vasega;ACS Vasega Solvents;Kaponi Uamea ma filo NPT;Me'a mamafa; Solvents mo LC- ICP-MS; Toxins (e ese mai i vailaau e tineia ai manu faalafua/fualaau fa'asaina); Talosaga; Su'esu'ega Meainu; Poloka Faufale; C4 i le C8; Fa'asologa Fa'ainisinia; Mea'ai &; GC-MS Solvents; Poloka Faufale Heterocyclic; ICP-OES/-MS; Pyrrolidines; Su'esu'ega mo Su'esu'ega Su'esu'ega; Solvents mo Su'esu'ega Fa'ameamea; Solvents mo Su'esu'ega Fa'apitoa (LC-ICP-MS); Spectroscopy; Su'esu'ega Su'ega Su'esu'e &; Anhydrous; Oloa; Su'ega Su'e; Amine; Heterocycles; Su'esu'ega Eseese; Solvents Anhydrous; Fa'aaogāga;Sui Malosiaga;Amber Glass Bottles;Analytical Reagents;Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV;Materials Products Sciences). Solvents Organic;Semi-Bulk Solvents;Solvent Fagu; Solvent Packaging Options;UHPLC Solvents (CHROMASOLV);NMR;Spectrophotometric Grade;Spectrophotometric Solvents;Spectroscopy Solvents (IR; Containe Returnable;Sure/Seal Bottles;Biollidons;BiotechsBiotechs;Spectrophotometric Grade; ;Ioe/Faamaufaailoga?Fagu;872-50-4;bc0001

Mol File:872-50-4.mol

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Fa'amatalaga Oloa

Faailoga o oloa

Pyrrolidone Chemical Properties

Liu liusuavai	-24 °C (malamalama)
Fa'apuna	202 °C (malamalama) 81-82 °C/10 mmHg (malamalama)
mafiafia	1.028 g/mL ile 25 °C (malamalama)
ausa mafiafia	3.4 (vs ea)
mamafa ausa	0.29 mm Hg (20 °C)
fa'asino fa'asino	n20/D 1.479
Fp	187 °F
vevela vevela.	Teu i le +5°C i le +30°C.
solubility	ethanol: miscible0.1ML/mL, manino, leai se lanu (10%, v/v)
fomu	Suavai
pka	-0.41±0.20(Vavaloa)
lanu	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20 ℃)
Sogisogi	Le manogi amine laititi
PH Va'aiga	7.7 - 8.0
tapula'a papa	1.3-9.5%(V)
Suavai Solubility	>=10 g/100 mL ile 20 ºC
Ma'ale'ale	Hygroscopic
λmax	283nm(MeOH)(malamalama)
Merck	14,6117
BRN	106420
Maumau:	Maumau, ae pala pe a fa'aalia i le malamalama.E mu.E le fetaui ma vailaʻau faʻamaʻi malosi, vailaʻau malosi, mea faʻaitiitia, faʻavae.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 ile 25℃
CAS Fa'amaumauga Fa'amaumauga	872-50-4(Fa'amatalaga Fa'amaumauga a le CAS)
NIST Chemistry Reference	2-Pyrrolidinone, 1-methyl-(872-50-4)
Faiga Fa'atusitala a le EPA	N-Methyl-2-pyrrolidone (872-50-4)

Fa'amatalaga Saogalemu

Laiti o lamatiaga	T,Xi
Fa'amatalaga Tulaga lamatia	45-65-36/38-36/37/38-61-10-46
Fa'amatalaga Saogalemu	41-45-53-62-26
WGK Siamani	1
RTECS	UY5790000
F	3-8-10
Fa'avevela le vevela	518 °F
TSCA	Y
HS Code	2933199090
Fa'amatalaga o Mea Mata'utia	872-50-4(Fa'amatalaga o Mea Mata'utia)
Oona	LD50 tuugutu ile Lapiti: 3598 mg/kg LD50 dermal Lapiti 8000 mg/kg

Pyrrolidone Fa'aoga ma Fa'asologa

Meatotino tau vailaau	O le N-Methyl-2-pyrrolidone o se vai e leai se lanu i le samasama malamalama ma sina manogi ammonia.N-Methyl-2-pyrrolidone e fa'afefiloi atoa ile vai.E sili ona solu i le ava maualalo, ketones maualalo, eter, ethyl acetate, chloroform, ma benzene ma feololo solo i aliphatic hydrocarbons.O le N-Methyl-2-pyrrolidone e malosi le hygroscopic, e mautu i kemikolo, e le pala i le uamea kaponi ma le alumini, ma sina pala i le kopa.E maualalo le adhesiveness, malosi kemikolo ma vevela mautu, polarity maualuga, ma volatility maualalo.O lenei oloa e fai sina oona, ma o lona fa'agata fa'atagaina ile ea e 100ppm. N-Methyl-2-pyrrolidone o se solvent o loʻo faʻaaogaina i le tele o alamanuia ma faʻaoga, e pei o le vali ma le faʻafefe o le ufiufi, faʻaogaina o le petrochemical, faʻapipiʻi palasitika faʻainisinia, vailaʻau faʻatoʻaga, faʻamamaina eletise ma fale gaosi oloa / fale.
Fa'aoga	N-Methyl-2-pyrrolidone (NMP) o se polar aprotic solvent o loʻo i ai le lelei o le maualalo o le oona, maualuga maualuga, solvency mataʻina, filifili malosi ma mautu lelei.E masani ona faʻaaogaina i le faʻamamaina o le faʻaaogaina o le hydrocarbon aromatic, acetylene, olefins, ma diolefins. E faʻaaogaina i le faʻamamaina o fale gaosimea, ma e avea o se solvent mo le gaosiga o vailaʻau faʻamaʻi, palasitika inisinia, paʻu, alava faʻapipiʻi, ma fesoʻotaʻiga tuʻufaʻatasia. E mafai foʻi ona faʻaaogaina e fai ma faʻamama fale gaosi oloa, faʻasalalau, vali, lubricant ma antifreeze. N-Methyl-2-pyrrolidone o se solvent sili ona lelei, faʻaaogaina lautele i le faʻaaogaina o mea manogi, faʻamamaina o le suauʻu lubricating, faʻatamaoaigaina acetylene, vavaeeseina o le butadiene ma le faʻaogaina o le gas desulfurization. E faʻaaogaina i le kesi desulfurization, lubricating suauu faamamaina, lubricating suauu antifreeze, olefin aveesea, ma o se solvent mo insoluble inisinia plastics polymerization. E mafai ona faʻaaogaina i le herbicide, e faʻamama ai mea faʻapipiʻi, semiconductor alamanuia saʻo meafaifaʻaili ma laupapa matagaluega, e toe faʻaaogaina le PVC faʻagogo, e fai ma vai, faʻaopoopoga faʻalanu ma sui faʻasalalau. E fa'aaogaina i alalaupapa mo tali fa'apolopolo e pei o palasitika fa'ainisinia ma alava aramid. O le N-Methyl-2-pyrrolidone o loʻo faʻaaogaina e avea o se polyvinylidene fluoride solvent ma electrode auxiliary mea mo maa lithium ion. tulaga mama maualuga mo le ICP-MS iloa. Mo le faʻapipiʻiina o le peptide.
oona	Tu'u gutu (mus)LD50:5130 mg/kg;Tuugutu (iole)LD50:3914 mg/kg; Dermal (rbt)LD50:8000 mg/kg.
Lafoa'iina o otaota	Fa'afeso'ota'i tulafono a le setete, fa'alotoifale po'o le atunu'u mo le lafoa'iina lelei.E tatau ona faia le lafoaia e tusa ai ma tulafono faatonutonu aloaia.Suavai, pe a manaʻomia faʻatasi ma mea faʻamamā.
teuina	N-Methyl-2-pyrrolidone e hygroscopic (e pikiina le susu) ae mautu i lalo o tulaga masani.O le a fa'afefeteina ma fa'ama'i fa'ama'i malolosi e pei o le hydrogen peroxide, nitric acid, sulfuric acid, ma isi mea.O le tele o le fa'aalia po'o le masaa e tatau ona 'alofia ona o se faiga lelei.Lyondell Chemical Company fautuaina le ofuina o totigilima butyl pe a fa'aogaina le N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone e tatau ona teuina i totonu o le u'amea mama po'o le pa'u pa'u mama.Teflon®1 ma Kalrez®1 ua faʻaalia o ni mea faʻapipiʻi talafeagai.Fa'amolemole iloilo le MSDS a'o le'i tagofia.
Fa'amatalaga	O le N-Methyl-2-pyrrolidone o se solvent aprotic ma le tele o mea faʻaoga: faʻaogaina o le petrochemical, faʻapipiʻi luga, vali ma pigments, faʻamama fale gaosi oloa ma fale, ma faʻatoʻaga ma vailaʻau.E masani lava o se fa'aitaitagofie, ae na mafua ai foi le tele o mataupu o le contact dermatitis i totonu o se kamupani eletise eletise.
Meatotino tau vailaau	O le N-Methyl-2-pyrrolidone o se vai e leai se lanu po o se vai samasama malamalama ma se manogi amine.E mafai ona o'o i le tele o gaioiga fa'a-kemikolo e ui lava e talia e avea o se solvent mautu.E tetee i le hydrolysis i lalo o tulaga le mautonu, ae o le malosi malosi poʻo le togafitiga faʻavae e maua ai le mama i le 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone e mafai ona faʻaititia i le 1-methyl pyrrolidine ma le borohydride.Togafitiga fa'atasi ai ma vaila'au fa'a-chlorinating e maua ai le fa'avaeina o le amide, o se vaeluaga e mafai ona toe suia atili, a'o togafitiga ma le amyl nitrate e maua mai ai le nitrate.Olefins e mafai ona faʻaopoopo i le tulaga 3 e ala i togafitiga muamua i esters oxalic, ona faʻatasi ai lea ma aldehyes talafeagai (Hort ma Anderson 1982).
Fa'aoga	O le N-Methyl-2-pyrrolidone o se mea faʻapipiʻi polar lea e faʻaaogaina i kemisi kemisi ma polymer kemisi.O talosaga tetele e aofia ai le toe faʻaleleia ma le faʻamamaina o acetylenes, olefins, ma diolefins, faʻamamaina o le kesi, ma le faʻaaogaina o mea manogi mai meaʻai.O le NMP o lo'o fa'amaonia i le taimi nei mo le fa'aaogaina na'o vaila'au fa'afoma'i.O le fa'amautuina o le fa'aogaina ma le metabolism o le NMP i le isumu o le a saofagā i le malamalama i le o'ona o lenei vaila'au fa'apitoa e ono a'afia ai le tagata i le fa'ateleina o aofa'i.
Fa'aoga	Solvent mo resini vevela maualuga;gaosiga petrochemical, i le microelectronics fabrication alamanuia, vali ma pigments, falegaosimea ma fale fa'amama fale;fua fa'ato'aga ma vaila'au
Fa'aoga	N-Methyl-2-pyrrolidone, e aoga mo spectrophotometry, chromatography ma ICP-MS suʻesuʻega.
Uiga	ChEBI: O se sui o le vasega o pyrrolidine-2-ones o le pyrrolidin-2-one lea e suia ai le hydrogen o loʻo faʻapipiʻi i le nitrogen i se vaega methyl.
Metotia o gaosiga	N-Methyl-2-pyrrolidone o loʻo gaosia e ala i le faʻaalia o le buytrolactone ma le methylamine (Hawley 1977).O isi faiga e aofia ai sauniuniga e ala i le hydrogenation o vaifofo o maleic po'o succinic acids ma le methylamine (Hort ma Anderson 1982).O tagata gaosiga o lenei vailaʻau e aofia ai Lachat Chemical, Inc, Mequon, Wisconsin ma le GAF Corporation, Covert City, Kalefonia.
Fa'asologa o Fa'amatalaga	Tetrahedron Letters, 24, i.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
Fa'amatalaga Lautele	N-Methyl-2-Pyrrolidone (NMP) o se malosi, solvent aprotic ma maualuga solvency, ma maualalo volatility.O lenei vai e leai ni lanu, maualuga le pupuna, maualuga le moli ma le vai maualalo o le ausa e ave ai se manogi e pei o le amine.O le NMP e maualuga le vailaʻau ma le vevela ma e faʻafefiloi atoa ma le vai i soʻo se vevela.O le NMP e mafai ona avea o se solu faʻatasi ma vai, ava malosi, glycol ethers, ketones, ma aromatic/chlorinated hydrocarbons.O le NMP e mafai ona toe fa'aaogaina e ala i le fa'amama ma faigofie ona fa'apala.E le maua le NMP i le lisi o Hazardous Air Pollutants (HAPs) o le 1990 Clean Air Act Amendments.
Gaioiga o le Ea & Suavai	Solu i le vai.
Reactivity Profile	O lenei amine o se faʻavae vailaʻau vaivai tele.O le N-Methyl-2-pyrrolidone e masani ona fa'ate'a le ga'o e fai ai masima ma vai.O le aofaʻi o le vevela o loʻo faʻaalia i le mole o amine i se faʻasalaga e tele lava e tutoʻatasi mai le malosi o le amine o se faʻavae.Amines atonu e le ogatasi ma isocyanates, mea fa'ameamea halogenated, peroxides, phenols (acidic), epoxides, anhydride, ma acid halides.O le hydrogen kasa mumu e gaosia e amine faʻatasi ma mea faʻaitiitia malosi, pei o hydride.
Tulaga lamatia	Tugā pa'u ma mata fa'afefe.Li'a papa-ona 2.2–12.2%.
Mata'utia Soifua Maloloina	O le manavaina o ausa vevela e mafai ona fa'afefe ai le isu ma le fa'a'i.O le inuina e mafua ai le ita o le gutu ma le manava.Fa'apa'i i mata e mafua ai le ita.O le fa'afeso'ota'i faifaipea ma le fa'aumi o le pa'u e maua ai se fa'aitaitagofie e le tumau.
Tulaga Afi	Tulaga Matautia Faapitoa o Oloa Mu: Oona oona o le nitrogen e mafai ona fausia i le afi.
Mumu ma le Pa	E le mu
Fa'aaogāga fa'apisinisi	1) N-Methyl-2-pyrrolidone o loʻo faʻaaogaina e avea o se mea faʻapipiʻi lautele dipolar aprotic solvent, faʻamautu ma le le gaoioi; 2) mo le fa'aaogaina o suau'u lubricating; 3) mo le aveeseina o le carbon dioxide i le ammonia generators; 4) e avea o se solvent mo tali polymerization ma polymers; 5) e pei o se vali vali; 6) mo vaila'au fa'atosina (USEPA 1985). O isi fa'aoga le fa'aogaina o le N-Methyl-2-pyrrolidone o lo'o fa'avae i luga o ona meatotino e pei o se solvent dissociating talafeagai mo su'esu'ega fa'aletino ma kemisi fa'aletino (Langan ma Salman 1987).O talosaga fa'afoma'i e fa'aogaina ai meatotino a le N-Methyl-2-pyrrolidone e fai ma fa'aleleia atili mo le vave fa'aliliuina o mea e ala i le pa'u (Kydoniieus 1987; Barry ma Bennett 1987; Akhter ma Barry 1987).O le N-Methyl-2-pyrrolidone ua fa'amaonia e avea o se vaifofo mo le fa'aogaina o le slimicide i mea e teu ai mea'ai (USDA 1986).
Fa'afeso'ota'i allergens	O le N-Methyl-2-pyrrolidone o se solvent aprotic ma le tele o mea faʻaoga: faʻaogaina o le petrochemical, faʻapipiʻi luga, vali ma pigments, faʻamama fale gaosi oloa ma fale, ma faʻatoʻaga ma vailaʻau.E masani lava ose fa'aitaitagofie, ae e mafai ona mafua ai le tuga o le contact dermatitis ona o le umi o feso'ota'iga.
Fa'amatalaga Saogalemu	Oona e ala ile tui toto.O'ona feololo e ala ile ingestion ma auala intraperitoneal.O'ona laititi pe a pa'i ile pa'u.O se teratogen faataitai.Fa'ata'ita'iga a'afiaga fa'afuafua.Fa'amatalaga o suiga na lipotia.E mu pe a fa'aalia i le vevela, mumu matala, po'o ni mea fa'amalama malosi.E tau ai le afi, fa'aaoga foam, CO2, vaila'au mago.A fa'avevela e pala e fa'asu'a mai ai le asu oona ole NOx.
Carcinogenicity	O iole na faʻaalia i le N-Methyl-2-pyrrolidone vapor i le 0, 0.04, poʻo le 0.4 mg / L mo le 6 h / aso, 5 aso / vaiaso mo le 2 tausaga. O tamaʻi iole i le 0.4 mg / L na faʻaalia teisi faʻaititia o le mamafa o le tino.Leai se fa'apu'upu'u o le ola oona po'o a'afiaga tuga na matauina i isumu fa'aalia mo le 2 tausaga i le 0.04 po'o le 0.4mg/L ole N-Methyl-2-pyrrolidone.I le auala dermal, o se vaega o isumu 32 na maua se tui amata o le 25mg o le N-Methyl-2-pyrrolidone sosoo ai ma le 2 vaiaso mulimuli ane e ala i talosaga a le tumo promoter phorbol myristate acetate, faatolu i le vaiaso, mo le sili atu i le 25 vaiaso.O le Dimethylcarbamoyl chloride ma le dimethylbenzanthracene sa avea ma fa'atonuga lelei.E ui lava o le vaega o le N-Methyl-2-pyrrolidone e tolu paʻu o le paʻu, o lenei tali e leʻo taua tele pe a faʻatusatusa i le faʻatonuga lelei.
Ala metabolic	O iole e fa'aigoaina i le leitio N-methyl-2-pyrrolidinone (NMP), ma o le auala tele e alu ese ai e isumu e ala i le mimi.O le metabolite tele, e fai ma sui o le 70-75% o le fua fa'atonu, o le 4-(methylamino)butenoic acid.O lenei oloa e le'i tumu e mafai ona fausia mai le aveesea o le vai, ma e mafai ona iai se vaega o le hydroxyl i luga o le metabolite a'o le'i faia le sua sua.
Metabolism	O tama'i iole Sprague-Dawley na tu'uina atu i ai se tui intraperitoneal e tasi (45 mg / kg) o le radiolabeled 1 -methyl-2-pyrrolidone.O le maualuga o le plasma o le leitio ma le faʻapipiʻi na mataʻituina mo le ono itula ma o faʻaiʻuga na faʻaalia ai se vaega faʻavavevave ona sosoʻo ai ma le faʻagesegese o le faʻaumatiaina.Ole aofa'iga tele ole fa'ailoga na fa'amama ile mimi ile 12 itula ma e tusa ma le 75% ole fua fa'ailoga.I le luasefulufa itula talu ona mae'a le tui, o le fa'aputuga o le fa'amama (urine) e tusa ma le 80% o le tui.Na faʻaaogaina uma ituaiga mama ma methyl-label, faʻapea foʻi ma [¹⁴C]- ma le [3H]-faailoga l-methyl-2-pyrrolidone.O fua fa'atatau muamua na fa'amauina i totonu o le 6 itula muamua ina ua mae'a le tui.Ina ua maeʻa le 6 itula, na maua i le ate ma le manava o loʻo i ai le faʻaputuga sili ona maualuga o le leitio, e tusa ma le 2-4% o le fua.E itiiti le leitio gaioioiga na maitauina i le ga'o po'o le ea manava.O le chromatography sua maualuga o le mimi na fa'aalia ai le iai o se metabolites tetele ma lua.O le metabolite tele (70-75% o le fua o le leitio fa'atonuina) na su'esu'eina e le chromatography-mass spectrometry ma le gas chromatography-mass spectrometry ma sa fuafuaina e avea ma 3- po o le 5-hydroxy-l-methyl-2-pyrrolidone (Wells). 1987).
Auala Fa'amamāina	Faamago le pyrrolidone e ala i le aveesea o vai e pei o le *benzene azeotrope.Fa'ato'a fa'a'ese'ese i le 10 torr i se koluma 100-cm o lo'o fa'atumuina i tioata tioata.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] O le hydrochloride ei ai m 86-88o (mai EtOH poʻo Me2CO / EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]